Perform with Dr. Andy Galpin
Huberman Lab

Run Faster, Go Further

12 episodes

Training protocols for runners — VO2max, zone 2, breathing techniques, and mobility work.

Training protocols for runners — VO2max, zone 2, breathing techniques, and mobility work.

Episodes

1
Perform with Dr. Andy Galpin
How to Improve Your VO2 Max & Build Endurance
Perform with Dr. Andy Galpin Andy Galpin 2024-06-26

Dr. Andy Galpin explains how to improve VO2 max and build endurance. Covers the physiology of aerobic capacity and training methods to enhance it.

2
Huberman Lab
Essentials: How to Build Endurance
Huberman Lab Andrew Huberman 2025-04-17

Andrew Huberman breaks down the science of endurance into four distinct categories: muscular endurance, long-duration endurance, high-intensity anaerobic conditioning, and high-...

3
#219 - Dr Phil Maffetone | Why Low Heart Rate Training Improves Your Running Performance
Relaxed Running 2024-02-15

Dr. Phil Maffetone, creator of the MAF Method, explains why building an aerobic base through low heart rate training transfers to faster race times over longer distances. The co...

4
From Breath Science to Peak Running Performance — With Dr Eric Harbour & Prof Paul Laursen
Training Science Podcast 2025-07-26

Dr. Eric Harbour and Prof. Paul Laursen discuss respiratory training and VO2max optimization for endurance runners, covering breathwork techniques that translate to peak running...

5
Isometrics vs. Strength vs. Plyos: What's Missing in Your Strength Training with Dr. Matt Silver
The Strength Running Podcast 2025-11-06

Physical therapist and cross-country athlete Dr. Matt Silver breaks down the distinct roles of isometric training, traditional strength work, and plyometrics for runners, and id...

6
Why Zone 2 Training is the Cardio Sweet Spot
The Longevity Link 2025-06-23

Compounding pharmacist Kris Gravant breaks down zone 2 cardio training for the general population, explaining why it has become the most discussed training zone in longevity cir...

7
Perform with Dr. Andy Galpin
How & Why to Strengthen Your Heart & Cardiovascular Fitness
Perform with Dr. Andy Galpin 2024-06-12

In the inaugural episode of Perform, Dr. Andy Galpin delivers a comprehensive guide to understanding and improving cardiovascular fitness. He opens with a deceptively simple que...

8
Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition
Zone 2 Training Explained: The Single Best Workout for Your Mitochondria | Dr. Inigo San Millan
Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition Inigo San Millan 2025-11-19

Sarah Macklin interviews Dr. Inigo San Millan on why mitochondrial function represents the next frontier beyond VO2 max for understanding health and longevity. San Millan explai...

9
FoundMyFitness
#082 The Science of Vigorous Exercise — Should We Train Hard or Train Long? | Martin Gibala, Ph.D.
FoundMyFitness Martin Gibala 2023-09-19

About 40% of people don't improve VO2 max from moderate exercise alone—they need intensity. HIIT triggers rapid mitochondrial growth and produces lactate that crosses into the b...

10
Huberman Lab
Fitness Toolkit: Protocol & Tools to Optimize Physical Health
Huberman Lab Andrew Huberman 2022-10-17

Build your weekly fitness around 150-200 minutes of zone 2 cardio (conversational pace, nasal breathing) plus strength training. Alternate emphasis every 10-12 weeks. Long zone ...

11
The Art of Manliness
Get Fit, Not Fried — The Benefits of Zone 2 Cardio
The Art of Manliness Alex Viada 2023-01-02

Brett McKay interviews hybrid athlete and coach Alex Viada on why most people skip zone 2 cardio entirely, jumping straight from rest to zone 3 and missing significant health an...

12
FoundMyFitness
#090 How Exercise Prevents & Reverses Heart Aging | Benjamin Levine, M.D.
FoundMyFitness Benjamin Levine 2024-05-28

Three weeks of bed rest causes worse cardiovascular decline than 30 years of aging. The flip side: exercising 4-5 days per week preserves youthful heart structure, and the Norwe...

Related Research

Markers of clinical and mitochondrial adaptation in response to moderate intensity continuous training: A systematic review and meta-analysis
Vabishchevich V, Smith RT, Bittel AJ (2026)
Across 14 studies (n=184), moderate-intensity continuous training significantly increased mitochondrial volume density (p<0.00001) and VO2max (p<0.0001), with modest gains in citrate synthase and MFN2, confirming Zone 2-type exercise drives meaningful mitochondrial adaptation.
Cardiorespiratory fitness, body mass index and mortality: a systematic review and meta-analysis.
Weeldreyer NR, De Guzman JC, Paterson C, et al. (2025)
Higher cardiorespiratory fitness is associated with lower all-cause mortality regardless of BMI, suggesting that fitness matters more than weight for longevity.
Effects of Nasal and Oral Breathing on Respiratory Muscle and Brain Function: A Review.
Bayrak Ö, Polastri M, Pehlivan E (2025)
Nasal breathing activates more brain regions during cognitive tasks (15 vs 10 areas), enhances default mode network connectivity, and produces more efficient diaphragmatic breathing compared to oral breathing.
High-intensity interval training and cardiorespiratory fitness in adults: An umbrella review of systematic reviews and meta-analyses.
Poon ET, Li H, Gibala MJ, et al. (2024)
HIIT produces large, consistent improvements in cardiorespiratory fitness across diverse adult populations, with effect sizes comparable to or greater than moderate-intensity continuous training.
The effect of pre-exercise oral hyperhydration on endurance exercise performance, heart rate, and thermoregulation: a meta-analytical review.
McCubbin AJ, Irwin C (2024)
Pre-exercise hyperhydration (including sodium loading) provides small-to-moderate improvement in endurance performance, with a Hedges' g of 0.31 for time-to-exhaustion tasks.
Chronic effects of stretching on range of motion with consideration of potential moderating variables: A systematic review with meta-analysis.
Konrad A, Alizadeh S, Daneshjoo A, et al. (2024)
Chronic stretching produces moderate ROM improvements (ES = 1.0), with PNF and static stretching significantly outperforming ballistic/dynamic stretching, while training dose variables show minimal impact.