Huberman Lab
FoundMyFitness
The Human Upgrade
The Dr. Layne Norton Podcast

Train Smarter After 40

12 episodes

Resistance training, joint preservation, testosterone, and recovery for the 40+ athlete. How to build and keep muscle as you age without destroying your body.

Resistance training, joint preservation, testosterone, and recovery for the 40+ athlete. How to build and keep muscle as you age without destroying your body.

Episodes

1
Huberman Lab
Essentials: How to Exercise for Strength Gains & Hormone Optimization | Dr. Duncan French
Huberman Lab Andrew Huberman 2025-09-18

The 6x10 protocol (6 sets of 10 reps with controlled rest) reliably boosts testosterone through training. Time your cold exposure strategically - it helps recovery but can blunt...

2
Huberman Lab
The Correct Way to Build Strength, Endurance & Flexibility at Any Age | Pavel Tsatsouline
Huberman Lab Pavel Tsatsouline 2025-02-10

Pavel Tsatsouline, world-renowned strength and conditioning coach and founder of StrongFirst, joins Andrew Huberman to discuss the most effective and efficient methods for build...

3
FoundMyFitness
#078 Resistance training for time efficiency, body composition, and maximum hypertrophy | Brad Schoenfeld, Ph.D.
FoundMyFitness Dr. Brad Schoenfeld 2022-12-06

Lighter weights can build as much muscle as heavy ones if you train close to failure. Get evidence-based protocols for maximizing hypertrophy in minimal time using supersets, dr...

4
FoundMyFitness
#081 The Anabolic Potential of Omega-3 Fatty Acids | Chris McGlory, PhD
FoundMyFitness Chris McGlory 2023-07-03

High-dose omega-3s (5g/day) cut muscle loss during immobilization by roughly 50%—but you need 4-6 weeks of preloading before they protect you. Especially valuable for older adul...

5
The Human Upgrade
The Secret Peptides and Underground Compounds Doctors Won’t Talk About : 1413
The Human Upgrade Dylan Gemelli 2026-02-10

Dave Asprey sits down with Dylan Gemelli for a wide-ranging conversation about peptides, research chemicals, SARMs, and the gray zone between medicine, performance enhancement, ...

6
The Dr. Layne Norton Podcast
The Keys to Building Muscle Part 1: TRAINING
The Dr. Layne Norton Podcast Layne Norton 2025-12-15

Dr. Layne Norton breaks down the key training principles for muscle hypertrophy. The evidence shows that more volume improves hypertrophy compared to lower volumes, but sets mus...

7
Modern Wisdom
Dr Mike Israetel - Exercise Scientist's Masterclass On Longevity
Modern Wisdom Dr. Mike Israetel 2024-12-02

Dr. Mike Israetel examines the truth about extending lifespan. As technology advances, living much longer feels within reach - but what does the latest science actually reveal? ...

8
Modern Wisdom
Dr Shanna Swan - Why Are Men’s Testosterone Levels Plummeting?
Modern Wisdom Dr Shanna Swan 2024-04-11

Dr Shanna Swan joins Modern Wisdom to discuss why are men’s testosterone levels plummeting?. Key topics include brain health optimization and neuroprotective strategies; hormona...

9
Strength & Scotch: Get Fitter While Enjoying Life
SS 139 - Occlusion Training... Silly or Science?
Strength & Scotch: Get Fitter While Enjoying Life 2017-08-07

Grant and Coach Brandon Heavey break down the science behind occlusion training (BFR) in their characteristically humorous style. Brandon explains how restricting venous blood f...

10
The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.
The Peter Attia Drive 2025-02-10

Dr. Mike Israetel shares his journey from powerlifting to exercise science academia and discusses core resistance training principles including exercise selection, volume, inten...

11
Wits & Weights | Evidence-Based Fitness & Nutrition for Lifters Over 40
Build Muscle Using Blood Flow Restriction (BFR Training for Lifters Over 40) | Ep 239
Wits & Weights | Evidence-Based Fitness & Nutrition for Lifters Over 40 2024-11-04

Philip Pape delivers a comprehensive practical guide to BFR training for lifters, covering everything from equipment selection to programming. He explains why auto-inflating cuf...

12
Barbell Medicine Podcast
Episode #385- Why Grip Strength Predicts Death (And Why You Shouldn't Train It)
Barbell Medicine Podcast Austin Baraki 2026-01-30

Dr. Jordan Feigenbaum and Dr. Austin Baraki of Barbell Medicine take a nuanced, contrarian look at grip strength as a health metric. They argue that grip strength is a thermomet...

Related Research

Markers of clinical and mitochondrial adaptation in response to moderate intensity continuous training: A systematic review and meta-analysis
Vabishchevich V, Smith RT, Bittel AJ (2026)
Across 14 studies (n=184), moderate-intensity continuous training significantly increased mitochondrial volume density (p<0.00001) and VO2max (p<0.0001), with modest gains in citrate synthase and MFN2, confirming Zone 2-type exercise drives meaningful mitochondrial adaptation.
The Effect of Creatine Supplementation on Resistance Training-Based Changes to Body Composition: A Systematic Review and Meta-analysis.
Desai I, Wewege MA, Jones MD, et al. (2025)
Creatine supplementation during resistance training increased lean body mass by 1.14 kg, reduced body fat percentage by 0.88%, and reduced fat mass by 0.73 kg compared to training alone.
Effect of Aerobic Training with Blood Flow Restriction on Strength and Hypertrophy: A Meta-analysis.
Teixeira Filho CAT, Junior EP, Vendrame JW, et al. (2024)
Aerobic training with blood flow restriction produces significant improvements in both muscle strength and hypertrophy compared to aerobic training alone.
Chronic effects of stretching on range of motion with consideration of potential moderating variables: A systematic review with meta-analysis.
Konrad A, Alizadeh S, Daneshjoo A, et al. (2024)
Chronic stretching produces moderate ROM improvements (ES = 1.0), with PNF and static stretching significantly outperforming ballistic/dynamic stretching, while training dose variables show minimal impact.
Resistance Training and Mortality Risk: A Systematic Review and Meta-Analysis.
Shailendra P, Baldock KL, Li LSK, et al. (2022)
Any resistance training reduces all-cause mortality by 15%, cardiovascular mortality by 19%, and cancer mortality by 14%, with a nonlinear dose-response relationship.
Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases: a systematic review and meta-analysis of cohort studies.
Momma H, Kawakami R, Honda T, et al. (2022)
Muscle-strengthening activities are associated with a 15% lower risk of all-cause mortality, with maximum risk reduction occurring at approximately 30-60 minutes per week.