Mitochondria
Mitochondrial health and energy production
Interventions
Red Light Therapy
Photobiomodulation using red (630-660nm) and near-infrared (810-850nm) light to enhance mitochondrial function, recovery, and brain health
Zone 2 Cardio
Low-intensity aerobic training that builds mitochondrial density, metabolic flexibility, and cardiovascular base without excessive fatigue
NMN / NAD+ Precursors
NAD+ precursors (NMN, NR) to boost cellular energy production, support DNA repair, and potentially slow aging processes
Near-Infrared Heat Lamp Therapy
Incandescent heat lamps emitting near-infrared light (700-1400nm) for combined photobiomodulation and radiant heat therapy. Deeper tissue penetration than LEDs, with heat as a feature rather than byproduct.
Studies
Biochemical Adaptations in Muscle. Effects of Exercise on Mitochondrial Oxygen Uptake and Respiratory Enzyme Activity in Skeletal Muscle
Foundational study demonstrating that endurance training doubles mitochondrial content in skeletal muscle, establishing the basis for Zone 2 benefits.
Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance
Just 2.5 hours of sprint intervals over 2 weeks produced similar endurance adaptations to 10.5 hours of traditional training.
Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans
Just 6 sessions of sprint interval training (2 weeks) doubled endurance capacity and significantly increased muscle oxidative enzymes.
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial
GlyNAC supplementation in older adults corrected glutathione deficiency and improved multiple hallmarks of aging.
Much Ado About Zone 2: A Narrative Review Assessing the Efficacy of Zone 2 Training for Improving Mitochondrial Capacity
Current evidence does not support Zone 2 as the uniquely optimal intensity for mitochondrial or fatty acid oxidative capacity; higher intensities may be critical for maximizing cardiometabolic benefits, especially at lower training volumes.
Experts
Podcast Episodes
This Brain Trick Feels Like Cheating - Microglia and Brain Health
with Dr. David Perlmutter
Caroline Alan - Minerals for Mitochondria, Hormones & Brain
with Caroline Alan
My Heavy Metal Detox Strategy
with Matt Blackburn
Lipofuscin: Cellular Kryptonite That Nobody Talks About
with Matt Blackburn
Kidney Failure: It is Damaged Mitochondria
with Matt Blackburn
Peptides, Biologics & Small Molecules You've *Never Heard Of* For Sleep, Mitochondria, Kidney Health & More, With Jim LaValle.
with Jim LaValle
#050 NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide
with Rhonda Patrick
The Methylene Blue Episode | Solo Biohacking Masterclass : 1366
with Dave Asprey
The TRUTH About What's *Really* Causing Your Fatigue & The "Root Cause" Protocol to Fix It, With Morley Robbins.
with Ben Greenfield
The WATER Hack That Boosts Mitochondria by 11%! : 1343
with Dave Asprey
This Brain Trick Feels Like Cheating (Do THIS) : 1402
with Dr. David Perlmutter
Inside the Mind of the Mad Scientist Rewriting Aging : 1401
with Dr. Theodore Achacoso & Boomer Anderson
Why 18-Year-Olds Wake Up Fresh (And You Don't) : 1410
with Christian Drapeau
Turn Off Your WiFi Tonight and See What Happens to Your Sleep : 1414
with Andy Mant & Katie Mant
Low-Carb Vs. High-Carb Battle — What's BETTER For Your Health & Metabolism: Fats or Sugar? with Dr. Eric Westman and Jay Feldman
with Dr. Eric Westman & Jay Feldman
The SUPERHUMAN Protocol That Declumps Cells, Hyperoxygenates The Body, Restores Cellular Wellness & *Much* More, With Gary Brecka (Best of LIFE Network's Experts!)
with Gary Brecka
This FASCINATING Molecule Originally Boosted Muscle & Endurance But Is *Now* Being Shown To Reverse Immune Aging?! Urolithin A With Dr. Anurag Singh
with Dr. Anurag Singh
Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation | Dr. Casey Means
with Dr. Casey Means
How to Enhance Your Immune System | Dr. Roger Seheult
with Dr. Roger Seheult
George Wiseman – Hydrogen The Missing Key To Your Health!
with George Wiseman
Morley Robbins – Healing Neurological Disorders Like Parkinson's, Alzheimers, Dementia & More By Regulating Copper & Iron
with Morley Robbins
Matt Maruca – Principles of the Light Diet! Can You Live On Light?
with Matt Maruca
Dr. Nasha Winters – How To Heal & Prevent Cancer Using The Multi-Layered Metabolic Approach
with Dr. Nasha Winters
255. Fake Lighting Is Sabotaging Your Natural Rhythm w/ Tristan Scott
with Tristan Scott
Methods of Reducing Chronic Stress with Dr Scott Sherr
with Dr Scott Sherr
Debunking Methylene Blue Fears with Dr Scott Sherr
with Dr Scott Sherr
Defining Cancer and Sharing Solutions
with Matt Blackburn
Deuterium Depletion to Extend Lifespan with Victor Sagalovsky
with Victor Sagalovsky
Melatonin the Masterful Molecule for Mitochondria with Dr Russel Reiter
with Dr Russel Reiter
205. Dr. Josh Axe: On Longevity Secrets, Mitochondrial Health, Peptide Therapy & Parasite Infections
with Gary Brecka
Aging is best explained by declining mitochondrial function over time.
with Chris Masterjohn
SSRI Withdrawal Is Mitochondrial Dysfunction
with Chris Masterjohn
Methylene Blue: Biohacker's Delight, or Playing With Fire?
with Chris Masterjohn
Leaky Gut, Mitochondria and Unlocking the Keto Code with Dr. Steven Gundry
with Dr. Steven Gundry
Red Light Therapy for Healthy Mitochondria, Skin, Inflammation & Sleep with Scott Chaverri
with Scott Chaverri
The Melatonin, Mitochondria, Sex Hormones and Inflammation Connection!
with David Jockers
How to Maximize the Health Benefits of Sauna Usage-Discussion between Jenna Greenfield and Dr. Mercola
with Jenna Greenfield
1163: Red Light, Near Infrared Light, Infrared Light, Saunas and More
The One About Sauna Use and Benefits - Short Episode
How *Not* To Microwave Yourself In A Sauna, Cooking Turkeys With Infrared Rays, Low EMF Saunas, Heat Detox Protocols & More!
with Raleigh Duncan and Andy Pace (Clearlight Saunas)
Best of Series - Near - Infrared Sauna Therapy
with Brian Richards