Mental Health
Anxiety, depression, and psychological wellbeing
Interventions
Accelerated TMS (Transcranial Magnetic Stimulation)
Intensive 5-day brain stimulation protocol using magnetic pulses to treat depression and anxiety, compressing months of traditional TMS into one week
SAD Lamp (Bright Light Therapy)
Bright light therapy devices that emit 10,000 lux to treat Seasonal Affective Disorder (SAD) and regulate circadian rhythms
N-Acetylcysteine (NAC)
A powerful glutathione precursor with evidence for respiratory health, mental health support, liver protection, and emerging research on biofilm disruption for gut issues
Studies
Association between naturally occurring lithium in drinking water and suicide rates: systematic review and meta-analysis of ecological studies
Meta-analysis confirms inverse association between lithium in drinking water and suicide rates across multiple populations.
Caveat emptor: Folate in unipolar depressive illness, a systematic review and meta-analysis
L-methylfolate supplementation shows promise as an adjunctive treatment for depression, particularly in patients with inadequate response to antidepressants.
Accelerated TMS for Depression: A systematic review and meta-analysis
Meta-analysis confirms accelerated TMS protocols are effective for depression with faster onset than traditional TMS.
Transcranial magnetic stimulation in anxiety and trauma-related disorders: A systematic review and meta-analysis
TMS shows promising results for anxiety disorders including GAD, panic disorder, and PTSD with various protocols.
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial.
SAINT protocol achieved 79% remission rate in treatment-resistant depression with effects appearing within days.
Research on the Intervention Effect of Vibroacoustic Therapy in the Treatment of Patients with Depression
Somatosensory music therapy (vibroacoustic) improved depressive symptoms, increased positive emotions, reduced negative emotions, and helped restore autonomic nervous system balance over 4 weeks.
Muscle relaxation therapy for anxiety disorders: It works but how?
Comprehensive review confirms PMR effectively reduces anxiety symptoms, though the exact mechanisms (muscle tension vs cognitive) remain debated.
Efficacy of Eye Movement Desensitization and Reprocessing for Patients with Posttraumatic Stress Disorder: A Meta-Analysis of Randomized Controlled Trials
Meta-analysis of 26 RCTs found EMDR significantly reduces PTSD symptoms compared to controls, with effects maintained at follow-up.
A meta-analysis of the contribution of eye movements in processing emotional memories
Meta-analysis confirmed eye movements during memory recall reduce emotional intensity, supporting the working memory theory of EMDR's mechanism.
Autogenic training: A meta-analysis of clinical outcome studies
Meta-analysis of 60 studies found autogenic training produces medium-to-large effects for anxiety, depression, and functional disorders.
Autogenic training for stress and anxiety: a systematic review
Systematic review found autogenic training moderately effective for stress and anxiety reduction, though methodological quality of studies was variable.
Breathwork-Induced Psychedelic Experiences Modulate Neural Dynamics
Largest breathwork study to date found SOMA breathwork produces psychedelic-like neural changes, with increased brain complexity during breath holds similar to psilocybin effects.
[Effect of Autogenic Training for Stress Response: A Systematic Review and Meta-Analysis].
Systematic review and meta-analysis of 21 studies found autogenic training significantly reduces anxiety and depression while increasing heart rate variability in adults.
Autogenic training to reduce anxiety in nursing students: randomized controlled trial.
Eight weeks of autogenic training significantly reduced both state and trait anxiety in nursing students compared to laughter therapy and no-intervention controls.
Experts
Podcast Episodes
Gary Brecka, Dr. Will Cole & Dr. Tara Swart Bieber Live at the Wellness Oasis Event
with Dr. Will Cole, Dr. Tara Swart Bieber
237. Andrew Glaze: On The Mental Health Benefits of Running 100 Miles Weekly
with Andrew Glaze
235. Kelly Slater: 11x World Surfing Champion Shares His Diet Protocol, Training Routine, and Recovery Tips
with Kelly Slater
Gary Brecka Live at the Biohacking 360 Conference 2025 in Romania
with Gary Brecka
Recap: How to maintain new habits in the New Year
with Dr. Tara Swart, Sarah Berry
Roland Griffiths, PhD — Facing Death, How Meditation and Psychedelics Can Help, and The Art of Living with Gratitude
with Dr. Roland Griffiths
Dr Andrew Huberman - The New Science Of Longevity, Resilience & Breaking Bad Habits
with Dr. Andrew Huberman
Dr Mike Israetel - Exercise Scientist's Masterclass On Motivation, Habits & Discipline
with Dr. Mike Israetel
Gut Health Unlocked: Microbiome Maxxing + the Power of Bitters
with Tina Anderson & Kiran Krishnan
Depression Starts In Your Mitochondria
with Chris Masterjohn
Dr. Joe Dispenza – How To Rewire Your Brain, Personality & Emotions To Heal
with Dr. Joe Dispenza
Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson
with Dr. Matthew Johnson
Essentials: Healthy Eating & Eating Disorders - Anorexia, Bulimia, Binging
with Andrew Huberman
How Nature & Other Physical Environments Impact Your Focus, Cognition & Health | Dr. Marc Berman
with Andrew Huberman
Essentials: Understanding & Conquering Depression
with Andrew Huberman
#047 Exercise as a Treatment for Depression
with Rhonda Patrick
Essentials: Understanding & Treating Addiction | Dr. Anna Lembke
with Dr. Anna Lembke
How to Grow From Doing Hard Things | Michael Easter
with Michael Easter
#041 Dr. Charles Raison on Depression, the Immune-Brain Interface & Whole-Body Hyperthermia
with Dr. Charles Raison
Why Motivation DOESN’T Work | Mental Biohacks : 1361
with Dave Asprey
The Strange Science Behind Tylenol and Heartbreak | Daniel Amen : 1358
with Daniel Amen
Healing From Grief & Loss | Dr. Mary-Frances O'Connor
with Dr. Mary-Frances O'Connor
The Science & Art of Comedy & Creativity | Tom Segura
with Tom Segura
Essentials: Understanding & Healing the Mind | Dr. Karl Deisseroth
with Dr. Paul Conti
How Different Diets Impact Your Health | Dr. Christopher Gardner
with Dr. Chris Palmer
How Genes Shape Your Risk Taking & Morals | Dr. Kathryn Paige Harden
with Dr. Kathryn Paige Harden
How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read Montague
with Dr. Read Montague
Strength Training for Kids & Building Lifelong Movement Skills
with Andy Galpin
The 12 Greatest Mood Boosters on Earth : 1397
with Lucas Aoun
Contracts of Love & Money That Make or Break Relationships | James Sexton
with James Sexton
What Pets Actually Want & Need | Dr. Karolina Westlund
with Dr. Karolina Westlund
Tools for Overcoming Substance & Behavioral Addictions | Ryan Soave
with Ryan Soave
How to Improve Your Vitality & Heal From Disease | Dr. Mark Hyman
with Dr. Mark Hyman
How to Find & Be a Great Romantic Partner | Lori Gottlieb
with Lori Gottlieb
Transform Your Mental Health With Diet & Lifestyle | Dr. Chris Palmer
with Dr. Chris Palmer
Improve Focus With Behavioral Tools & Medication for ADHD | Dr. John Kruse
with Dr. John Kruse
Essentials: How Foods & Nutrients Control Our Moods
with Andrew Huberman
Essentials: Understand and Use Dreams to Learn and Forget
with Andrew Huberman
Essentials: Master Your Sleep & Be More Alert When Awake
with Andrew Huberman
How to Navigate Menopause & Perimenopause for Maximum Health & Vitality | Dr. Mary Claire Haver
with Dr. Mary Claire Haver
How to Find Your True Purpose & Create Your Best Life | Dr. James Hollis
with Dr. James Hollis
Vaping, Alcohol Use & Other Risky Youth Behaviors | Dr. Bonnie Halpern-Felsher
with Dr. Bonnie Halpern-Felsher
How to Master Growth Mindset to Improve Performance | Dr. David Yeager
with Dr. David Yeager
Overcoming Physical & Emotional Challenges | Coleman Ruiz
with Coleman Ruiz
How to Enhance Focus and Improve Productivity | Dr. Cal Newport
with Dr. Cal Newport
How to Build Immense Inner Strength | David Goggins
with David Goggins
How to Achieve Inner Peace & Healing | Dr. Richard Schwartz
with Dr. Richard Schwartz
Essentials: The Science of Emotions & Relationships
with Andrew Huberman
Using Your Mind to Control Your Physical Health & Longevity | Dr. Ellen Langer
with Dr. Ellen Langer
Essentials: How to Increase Motivation & Drive
with Andrew Huberman
Essentials: Tools for Managing Stress & Anxiety
with Andrew Huberman
Overcoming Guilt & Building Tenacity in Kids & Adults | Dr. Becky Kennedy
with Dr. Becky Kennedy
How to Best Guide Your Life Decisions & Path | Dr. Jordan Peterson
with Dr. Jordan Peterson
How to Achieve True Happiness Using Science-Based Protocols | Dr. Laurie Santos
with Dr. Laurie Santos
Understand & Apply the Psychology of Money to Gain Greater Happiness | Morgan Housel
with Morgan Housel
How to Control Your Inner Voice & Increase Your Resilience | Dr. Ethan Kross
with Dr. Ethan Kross
How Relationships Shape Your Brain | Dr. Allan Schore
with Dr. Allan Schore
How to Deal With High Conflict People | Bill Eddy
with Bill Eddy
Create Your Ideal Future Using Science-Based Protocols | Ari Wallach
with Ari Wallach
How to Heal From Post-Traumatic Stress Disorder (PTSD) | Dr. Victor Carrión
with Dr. Victor Carrion
How to Find, Build & Maintain Healthy Romantic Relationships | Esther Perel
with Esther Perel
How to Increase Your Emotional Intelligence | Dr. Marc Brackett
with Dr. Marc Brackett
How to Cultivate a Positive, Growth-Oriented Mindset | Dr. Jamil Zaki
with Dr. Jamil Zaki
Access Your Best Self With Mind-Body Practices, Belief Testing & Imagination | Dr. Martha Beck
with Dr. Martha Beck
How Cannabis Impacts Health & the Potential Risks | Dr. Matthew Hill
with Dr. Matthew Hill
How Smartphones & Social Media Impact Mental Health & the Realistic Solutions | Dr. Jonathan Haidt
with Dr. Jonathan Haidt
GUEST SERIES | Dr. Matt Walker: The Science of Dreams, Nightmares & Lucid Dreaming
with Dr. Matt Walker
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
with Dr. Matt Walker
How Placebo Effects Work to Change Our Biology & Psychology
with Andrew Huberman
Protocols for Excellent Parenting & Improving Relationships of All Kinds | Dr. Becky Kennedy
with Dr. Becky Kennedy
The Biology of Social Interactions and Emotions | Dr. Kay Tye
with Dr. Kay Tye
Journal Club with Dr. Peter Attia | Effects of Light & Dark on Mental Health & Treatments for Cancer
with Dr. Peter Attia
The Causes & Treatments for Autism | Dr. Karen Parker
with Dr. Karen Parker
A Process for Finding & Achieving Your Unique Purpose | Robert Greene
with Robert Greene
#731: Dr. David Spiegel, Stanford U. — Practical Hypnosis, Meditation vs. Hypnosis, Pain Management Without Drugs, The Neurobiology of Trance, and More
with Dr. David Spiegel
#673: Dr. Nora Volkow — Director of the National Institute on Drug Abuse (NIDA)
with Dr. Nora Volkow
#667: Dr. Gül Dölen on Rethinking Psychedelics, New Applications (Autism, Stroke, and Allergies), The Neurobiology of Beginner's Mind, Octopuses on MDMA, and The Master Key of Metaplasticity
with Dr. Gul Dolen
156. How to correct the root cause of your depression/anxiety/eating disorder
with Paul Saladino
Q&A: What the Anti PUFA Crowd Gets Wrong and Melatonin Dosing for Kids
with Matt Blackburn
How to Safely Perform a Liver Flush with Elizabeth Wells
with Elizabeth Wells
Order of Operations Matters with Detoxification with Kyle Peche
with Kyle Peche
Dr Sarah Hill - The Period Brain: How Hormones Change Women’s Behaviour
with Dr Sarah Hill
Dr Lisa Feldman Barrett - The New Science Of Emotions, Anxiety & Brain Health
with Dr Lisa Feldman Barrett
Dr Daniel Amen - The 11 Risk Factors That Are Destroying Your Brain
with Dr Daniel Amen
Dr Russell Kennedy - How To Fix Your Brain’s Addiction To Anxiety & Worry
with Dr Russell Kennedy
Doctor Mike - Reacting To The Rise Of Anxiety, Microplastics & Antidepressants
with Doctor Mike
Shawn Stevenson - How To Hack Your Sleep With These Habits
with Shawn Stevenson
Max Lugavere - The Terrifying Link Between Diet & Mental Health
with Max Lugavere
Anna Lembke - How To Reset Your Brain's Dopamine Balance
with Anna Lembke
222. How Daily Gratitude Lowers Stress, Anxiety and Depression (Science-Backed)
with Gary Brecka
The science of winter depression with Prof. Debra Skene – leading chronobiologist
with Jonathan Wolf
SSRI Withdrawal Is Mitochondrial Dysfunction
with Chris Masterjohn
Women's Hormonal Balance for Anxiety, Sleep & Fat Loss | Dr. Elana Zinkov
with Dr. Elana Zinkov
TMHS 884: How Your Microbiome Controls Your Mental Health & The Gut-Brain Paradox - With Dr. Steven Gundry
with Dr. Steven Gundry
Step by Step: Unlocking the Power of Walking with Ethan Suplee
The Science Of Walking: The Benefits Of Walking In Nature, Walking Meetings, And Walking Meditation | Dacher Keltner
with Dacher Keltner
Neuroscientist Reveals the Insane Benefits of Walking Everyday for Brain Health and Longevity with Shane O'Mara
with Shane O'Mara
Is Nicotine Actually...Good for You? New Research on Memory, Focus, and Mental Health
with Dr. Paul Newhouse
The Wim Hof Method - with Wim Hof| EP 108
with Wim Hof
How to Use Cold Therapy and Breathwork to Prevent Disease and Stagnation with Wim Hof
with Wim Hof
Wim Hof, The Iceman: Hack Your Biochemistry | E175
with Wim Hof
Wim Hof
with Wim Hof
Wim Hof ON: The One Simple Method To Improve Your Focus, Strength and Confidence
with Wim Hof
Using Deliberate Cold Exposure for Health and Performance
TMHS 792 - Boost Fat Loss, Improve Mental Health, & Extend Your Lifespan With Thermogenesis
with Susanna Soberg
TMHS 674: How to Utilize Cold Therapy to Burn Fat, Reduce Inflammation, & Build Confidence – with Dr. Susanna Søberg
with Susanna Soberg
How Deliberate Cold Exposure Healed My Autoimmune Conditions With Adrienne Jezick
with Adrienne Jezick