Interventions

Cold Exposure

Cold water immersion and cold showers for recovery, mood, and metabolic health

A

Sauna

Heat exposure via Finnish or infrared sauna for cardiovascular health, recovery, and longevity

A

Red Light Therapy

Photobiomodulation using red (630-660nm) and near-infrared (810-850nm) light to enhance mitochondrial function, recovery, and brain health

B

Creatine

The most well-researched sports supplement, proven to increase strength, power, and muscle mass with emerging cognitive benefits

A

Caffeine

The world's most popular psychoactive compound, proven to enhance alertness, focus, endurance, and strength performance

A

CO2 Tolerance Training

Breathing exercises to increase carbon dioxide tolerance, reducing anxiety, improving oxygen delivery, and enhancing breath-hold capacity

B

HRV Training

Using heart rate variability biofeedback to train your nervous system and monitoring daily HRV to optimize recovery and training decisions

B

Nicotine

Using low-dose nicotine (gum, pouches, or patches) as a cognitive enhancer for focus, attention, and memory - separate from smoking or tobacco use

B

VO2max Training

High-intensity interval training protocols designed to improve your maximal oxygen uptake (VO2max) - the single strongest predictor of longevity and one of the most trainable fitness markers

A

Rucking

Walking with a weighted backpack - combining Zone 2 cardio benefits with resistance training for a simple, low-impact exercise that builds strength-endurance and burns more calories than regular walking

B

Cyclic Sighing

A specific breathing pattern (double inhale, long exhale) shown by Stanford research to reduce stress more effectively than meditation

A

Nasal Breathing

Breathing through your nose instead of mouth for nitric oxide production, better oxygen delivery, and improved sleep

A

Walking (10,000 Steps)

Daily walking target of ~10,000 steps for all-cause mortality reduction, metabolic health, and cognitive function

A

Balance Training

Vestibular and proprioceptive training for fall prevention, athleticism, and brain health

B

Vagus Nerve Stimulation (VNS)

Electrical or mechanical stimulation of the vagus nerve to reduce inflammation, improve mood, and enhance parasympathetic tone

B

Non-Sleep Deep Rest (NSDR)

Guided relaxation protocol that enhances dopamine, reduces cortisol, and can partially compensate for lost sleep

B

Delayed Caffeine Protocol

Delaying morning caffeine 90-120 minutes after waking to optimize alertness and avoid afternoon crashes

C

Exogenous Ketones

Supplemental ketone bodies (BHB salts or esters) that rapidly elevate blood ketones for cognitive enhancement, endurance performance, and metabolic benefits

B

SOMA Breath

Rhythmic breathwork protocol combining ancient pranayama with music, using intermittent hypoxic training for stress reduction, cognitive enhancement, and altered states

B

Box Breathing (Tactical Breathing)

Equal-duration inhale, hold, exhale, hold pattern for rapid stress reduction, focus enhancement, and autonomic nervous system regulation

B

Hyperbaric Oxygen Therapy (HBOT)

Breathing pure oxygen at elevated pressure to enhance healing, reverse aging markers, and improve brain function

B

Magnesium

Essential mineral for 300+ enzymatic reactions, sleep quality, muscle function, and stress resilience

A

Mindfulness Meditation

Present-moment awareness training that reduces stress, improves focus, and changes brain structure with consistent practice

A

Accelerated TMS (Transcranial Magnetic Stimulation)

Intensive 5-day brain stimulation protocol using magnetic pulses to treat depression and anxiety, compressing months of traditional TMS into one week

B

BOLT Test (Body Oxygen Level Test)

A simple breath-hold assessment developed by Patrick McKeown to measure CO2 tolerance and breathing efficiency, used to track progress in breathing training

B

Low-Dose Lithium Orotate

Microdose lithium supplementation (1-20mg) for mood stability, neuroprotection, and potential longevity benefits based on population studies linking lithium in drinking water to reduced suicide and dementia rates

B

Tai Chi

Ancient Chinese martial art using slow, flowing movements for balance, fall prevention, stress reduction, and overall health, particularly beneficial for older adults

A

Yoga

Ancient Indian practice combining physical postures, breathing techniques, and meditation for flexibility, strength, stress reduction, and overall wellbeing

A

Matcha

Japanese powdered green tea providing calm, focused energy through the synergistic combination of L-theanine and caffeine, plus potent antioxidants

A

Methylation Support

Supporting the methylation cycle with targeted B vitamins and cofactors, especially important for those with MTHFR gene variants

B

Neurofeedback

EEG-based brain training that uses real-time feedback to help you learn to regulate brainwave patterns, improving focus, reducing anxiety, and enhancing cognitive performance

B

Tapping (EFT)

Emotional Freedom Technique (EFT) combines acupressure point tapping with cognitive reframing to reduce stress, anxiety, PTSD symptoms, and phobias by disrupting the body's stress response

B

MCT Oil

Medium-chain triglycerides rapidly convert to ketones, providing an alternative brain fuel for cognitive enhancement, sustained energy, and metabolic flexibility

B

L-Theanine

Amino acid from tea that promotes calm focus, reduces anxiety, enhances sleep quality, and synergizes powerfully with caffeine for cognitive performance

A

Ketogenic Diet

Very low-carbohydrate, high-fat diet that shifts metabolism to fat and ketone burning for cognitive clarity, metabolic health, and weight management

B

Float Tanks (Sensory Deprivation)

Floating in an enclosed tank of body-temperature Epsom salt water to eliminate sensory input, inducing deep relaxation, reduced stress hormones, pain relief, and enhanced creativity

B

CBD Oil

Non-psychoactive cannabinoid from hemp with evidence for anxiety reduction, sleep improvement, pain management, and inflammation - one of the most popular wellness supplements despite regulatory complexity

B

Bates Method (Vision Training)

Eye relaxation and vision training exercises developed by Dr. William Bates, aimed at improving eyesight naturally through relaxation, movement, and mental techniques

C

Progressive Muscle Relaxation (PMR)

Systematic tensing and releasing of muscle groups to reduce anxiety, improve sleep, and lower physical tension through increased body awareness

A

EMDR (Eye Movement Desensitization and Reprocessing)

Trauma processing therapy using bilateral stimulation (eye movements, tapping, or sounds) while recalling distressing memories to reduce their emotional charge

A

Autogenic Training

Self-hypnosis relaxation technique using verbal formulas to induce sensations of heaviness, warmth, and calm throughout the body

B

Intranasal Light Therapy

Delivering red or near-infrared light through the nasal cavity to target the brain, blood, and sinuses for cognitive enhancement and systemic benefits

C

Studies

Sauna bathing is inversely associated with dementia and Alzheimer's disease in middle-aged Finnish men

Men using sauna 4-7 times weekly had 65% lower risk of dementia and 66% lower risk of Alzheimer's disease compared to once-weekly users.

Laukkanen T (2017)

Shining light on the head - Photobiomodulation for brain disorders

Comprehensive review explaining how red/NIR light penetrates the skull to enhance mitochondrial function and potentially benefit various brain conditions.

Hamblin MR (2016)

Brain photobiomodulation therapy - A narrative review

Review of transcranial photobiomodulation showing potential for cognitive enhancement in healthy individuals and therapeutic benefits in various brain conditions.

Salehpour F (2019)

Effects of creatine supplementation on cognitive function of healthy individuals

Systematic review finding creatine improves short-term memory and reasoning, with strongest effects under stress conditions like sleep deprivation.

Avgerinos KI (2018)

A review of caffeine's effects on cognitive, physical and occupational performance

Comprehensive review showing caffeine improves alertness, attention, reaction time, and cognitive performance, particularly when fatigued or sleep-deprived.

McLellan TM (2017)

The role of deep breathing on stress

Diaphragmatic breathing significantly reduced cortisol levels and improved sustained attention compared to a control group.

Perciavalle V (2017)

Blue-Enriched White Light in the Workplace Improves Self-Reported Alertness, Performance and Sleep Quality

Workers exposed to blue-enriched light during the day reported better alertness, mood, and nighttime sleep quality compared to standard white light.

Viola AU (2008)

The Effect of Diaphragmatic Breathing on Attention, Negative Affect and Stress in Healthy Adults

8 weeks of diaphragmatic breathing training significantly reduced cortisol levels, improved sustained attention, and decreased negative affect in healthy adults.

Ma X (2017)

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress, A Systematic Review

Systematic review finding suggestive but not definitive evidence that magnesium supplementation may reduce subjective anxiety, with effects most pronounced in vulnerable populations.

Boyle NB (2018)

Dietary magnesium and calcium intake and risk of depression in the general population: A meta-analysis

Meta-analysis of 8,894 cases finding that higher dietary magnesium intake is significantly associated with lower risk of depression.

Li B (2017)

Hyperbaric Oxygen Therapy for Treating Neurocognitive Deficits in Traumatic Brain Injury Patients - A Systematic Review and Meta-analysis

Meta-analysis found HBOT significantly improves neurocognitive deficits in TBI patients compared to baseline.

Shahid S (2025)

The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers

3g glycine improved next-day cognitive performance and reduced fatigue in sleep-restricted subjects.

Bannai M (2012)

Efficacy and Safety of Exogenous Ketones in People with Mild Neurocognitive Disorder and Alzheimer's Disease

Exogenous ketones show promise for cognitive function in MCI/Alzheimer's, though study heterogeneity limits firm conclusions.

Krolak-Salmon P (2025)

Cognitive enhancement of healthy older adults using hyperbaric oxygen - a randomized controlled trial

HBOT improved cognitive function and increased cerebral blood flow in healthy adults over 64, suggesting oxygen therapy benefits brain aging.

Hadanny A (2021)

Association of Lithium in Drinking Water With the Incidence of Dementia

Higher lithium levels in drinking water associated with lower dementia incidence in Danish population study of 800,000+ people.

Kessing LV (2017)

Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders

Comprehensive review of lithium's neuroprotective mechanisms including GSK-3β inhibition, BDNF upregulation, and autophagy enhancement.

Forlenza OV (2015)

An intervention study on the effect of matcha tea, in drink and snack bar formats, on mood and cognitive performance

Matcha improves attention, reaction time, and memory within 1 hour of consumption in a dose-dependent manner.

Dietz C (2019)

The Impact of Active Workstations on Workplace Productivity and Performance: A Systematic Review

Sit-stand desks do not negatively impact productivity and may improve worker energy, focus, and comfort.

Ojo SO (2018)

Transcranial magnetic stimulation in anxiety and trauma-related disorders: A systematic review and meta-analysis

TMS shows promising results for anxiety disorders including GAD, panic disorder, and PTSD with various protocols.

Cirillo P (2020)

Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial.

SAINT protocol achieved 79% remission rate in treatment-resistant depression with effects appearing within days.

Cole EJ (2022)

Yoga for anxiety: A systematic review and meta-analysis of randomized controlled trials

Yoga significantly reduces anxiety symptoms with moderate effect sizes, comparable to other active treatments.

Cramer H (2018)

Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients

60 sessions of HBOT improved cognitive function, memory, and attention in post-stroke patients, with benefits persisting at follow-up.

Hadanny A (2021)

Association of daily step count and intensity with incident dementia

Walking ~10,000 steps daily was associated with 51% lower dementia risk, with benefits starting at just 3,800 steps per day.

del Pozo Cruz B (2022)

Young blood reverses age-related impairments in cognitive function and synaptic plasticity

Groundbreaking study showing exposure to young blood reversed age-related cognitive decline and enhanced neuroplasticity in aged mice.

Villeda SA (2014)

Efficacy of Neurofeedback Treatment in ADHD: The Effects on Inattention, Impulsivity and Hyperactivity: A Meta-Analysis

Neurofeedback produces large effect sizes for inattention and impulsivity in ADHD, comparable to medication effects.

Arns M (2009)

EEG-neurofeedback for optimising performance. I: a review of cognitive and affective outcome in healthy participants

Neurofeedback training improves performance in music, dance, acting, and sports through enhanced attention and anxiety regulation.

Gruzelier JH (2015)

What is Neurofeedback: An Update

Comprehensive review documenting neurofeedback efficacy for anxiety, depression, ADHD, and other conditions with lasting effects.

Hammond DC (2011)

Sustained Effects of Neurofeedback in ADHD: A Systematic Review and Meta-Analysis

Neurofeedback effects in ADHD are sustained at follow-up (6-12 months), unlike medication effects which require ongoing treatment.

Van Doren J (2019)

Daytime Alertness, Mood, Psychomotor Performances, and Oral Temperature During Ramadan Intermittent Fasting

Ramadan intermittent dry fasting affects circadian rhythms and alertness patterns but does not significantly impair cognitive function.

Roky R (2000)

The Effect of Emotional Freedom Techniques on Stress Biochemistry: A Randomized Controlled Trial

A single hour of EFT tapping reduced cortisol levels by 24% compared to talk therapy or rest, demonstrating measurable physiological stress reduction.

Church D (2013)

A Systematic Review of Clinical EFT (Emotional Freedom Techniques) and PTSD

EFT shows very large effect sizes (d=2.96) for PTSD treatment, with most participants no longer meeting diagnostic criteria after treatment.

Nelms JA (2016)

Emotional Freedom Techniques for Anxiety: A Systematic Review With Meta-analysis

EFT demonstrates large treatment effects for anxiety (d=1.23), significantly outperforming control conditions across 14 randomized controlled trials.

Clond M (2016)

Shilajit - A natural phytocomplex with potential procognitive activity

Review of shilajit's neuroprotective potential, highlighting fulvic acid's ability to inhibit tau protein aggregation - a key mechanism in Alzheimer's disease.

Carrasco-Gallardo C (2012)

Dietary Ketosis Enhances Memory in Mild Cognitive Impairment

Low-carbohydrate diet improved verbal memory in older adults with mild cognitive impairment, with improvements correlated to ketone levels

Krikorian R (2012)

Examining the short-term anxiolytic and antidepressant effect of Floatation-REST

A single float session produced significant and substantial reductions in anxiety and improvements in mood across 50 participants with anxiety and stress-related disorders.

Feinstein JS (2018)

Beneficial effects of treatment with sensory isolation in flotation-tank as a preventive health-care intervention

12 flotation sessions over 7 weeks significantly reduced stress, depression, anxiety, and pain while improving optimism and sleep quality.

Kjellgren A (2014)

Flotation-REST: Effects on and side-effects from 50 sessions of treatment

Long-term float therapy study showing cumulative benefits with continued practice, with stress reduction and well-being improvements persisting after 50 sessions.

Jonsson K (2016)

N-acetyl cysteine for depressive symptoms in bipolar disorder--a double-blind randomized placebo-controlled trial

NAC supplementation improved symptoms in schizophrenia patients, supporting its role in psychiatric conditions involving oxidative stress and glutathione deficiency.

Berk M (2009)

N-acetyl cysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

Comprehensive review established NAC's potential therapeutic role across multiple psychiatric conditions through glutathione replenishment, glutamate modulation, and anti-inflammatory effects.

Dean O (2011)

Increased dopamine tone during meditation-induced change of consciousness

Yoga Nidra meditation increased endogenous dopamine release by 65% in the ventral striatum, providing a neurobiological basis for its mood-enhancing effects.

Kjaer TW (2004)

Brief, daily meditation enhances attention, memory, mood, and emotional regulation in non-experienced meditators

Just 13 minutes of daily guided meditation for 8 weeks improved attention, working memory, and mood in meditation novices.

Basso JC (2019)

Relaxation training for anxiety: a ten-years systematic review with meta-analysis

Progressive muscle relaxation and other relaxation techniques show medium to large effect sizes for anxiety reduction across 27 studies.

Manzoni GM (2008)

Psychological therapies for chronic post-traumatic stress disorder (PTSD) in adults

EMDR and trauma-focused CBT are both effective first-line treatments for PTSD, with EMDR showing comparable efficacy and potentially faster results.

Bisson JI (2014)

Breathwork-Induced Psychedelic Experiences Modulate Neural Dynamics

Largest breathwork study to date found SOMA breathwork produces psychedelic-like neural changes, with increased brain complexity during breath holds similar to psilocybin effects.

Lewis-Healey E (2024)

Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation

Combined transcranial and intranasal photobiomodulation improved cognitive function in dementia patients

Saltmarche AE (2018)

Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations

Intranasal and transcranial photobiomodulation modulates brain oscillations associated with cognitive function

Zomorrodi R (2020)

Effect of tai chi on cognitive performance in older adults: systematic review and meta-analysis.

Tai Chi produces large improvements in executive function (Hedges' g = 0.90) in cognitively healthy older adults and moderate improvements even compared to other exercise (g = 0.51).

Wayne PM (2014)

Effects of Nasal and Oral Breathing on Respiratory Muscle and Brain Function: A Review.

Nasal breathing activates more brain regions during cognitive tasks (15 vs 10 areas), enhances default mode network connectivity, and produces more efficient diaphragmatic breathing compared to oral breathing.

Bayrak Ö (2025)

Qigong-Based Therapy for Treating Adults with Major Depressive Disorder: A Meta-Analysis of Randomized Controlled Trials.

Qigong therapy significantly reduces depression severity in adults with major depressive disorder, with a moderate-to-large effect size (Hedges' g = -0.64) compared to both active and passive controls.

Guo L (2019)

The therapeutic potential of matcha tea: A critical review on human and animal studies.

Critical review finds matcha decreases stress, slightly enhances attention and memory, reduces weight gain, improves lipid profiles, and shows anti-cancer properties through EGCG and L-theanine.

Sokary S (2023)

Effect of matcha green tea on cognitive functions and sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months.

12-month double-blind RCT in 99 older adults shows matcha consumption significantly improves social acuity and sleep quality, though primary cognitive endpoints (MoCA) did not reach significance.

Uchida K (2024)

Can transcranial photobiomodulation improve cognitive function? A systematic review of human studies.

29 of 35 human studies (83%) found that transcranial photobiomodulation improved cognitive function, with strongest evidence in dementia and mild cognitive impairment

Lee T (2022)

Photobiomodulation in the aging brain: a systematic review from animal models to humans.

Photobiomodulation demonstrates neuroprotective, anti-inflammatory, and mitochondrial-restoring effects in the aging brain, improving working memory, cognitive inhibition, and general cognition in both animal models and humans

Rodríguez-Fernández L (2024)

Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial.

Home-based transcranial and intranasal photobiomodulation improved cognitive function, reduced neuropsychiatric symptoms, and increased cerebral perfusion in dementia patients over 12 weeks

Chao LL (2020)

The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.

Meta-analysis of 16 RCTs found creatine supplementation significantly improved memory (SMD = 0.31), attention time, and processing speed, with greater benefits in diseased populations and females.

Xu C (2024)

Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials.

Meta-analysis of 10 RCTs found creatine supplementation improved memory (SMD = 0.29, p = 0.02), with the strongest effects in older adults aged 66-76 (SMD = 0.88) and minimal effects in younger individuals.

Prokopidis K (2023)

Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials.

Meta-analysis of 7 RCTs (325 participants) found magnesium supplementation significantly reduces depression scores (SMD -0.92, p=0.001).

Moabedi M (2023)

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